Arthur J. Weber, Ph.D.
Professor, College of Human Medicine, Department of Physiology
Glaucoma is a blinding disease characterized, in many cases, by pressure-induced trauma to the optic nerve posterior to the globe. Past research in my lab has focused on the structure-function relations that characterize neuronal degeneration within the central visual pathway following damage to the optic nerve. These studies combined conventional histological methods with intracellular recording and labeling, confocal microscopy, and video-enhanced image analysis. Our more recent work has focused on the development of treatment strategies aimed at mitigating or preventing optic nerve-related retinal degeneration and loss of visual function via the delivery of neuroprotectants to the diseased visual system. These studies employ an in vivo partial nerve crush model, osmotic mini-pump drug delivery, standard histological techniques, non-invasive electrophysiological analyses, Western blot, laser micro-dissection, and real time RT-PCR methods, to better understand the mechanisms of trauma-induced cellular degeneration and neuroprotection. Additional studies are aimed at the development of non-invasive approaches for enhancing endogenous neuroprotective mechanisms within the central visual pathway.
Weber, A.J. and C.D. Harman (2005) Structure-function relations of parasol cells in the normal and glaucomatous primate retina. Invest. Ophthalmol. Vis. Sci. 46:3197-3207.
Weber, A.J. and C.D. Harman (2008) BDNF preserves the dendritic morphology of α and β ganglion cells in the cat retina after optic nerve injury. Invest. Ophthalmol. Vis. Sci. 49:2456-2463.
Weber, A.J., C.D. Harman, and S. Viswanáthan (2008) Effects of optic nerve injury, glaucoma, and neuroprotection on the survival, structure, and function of ganglion cells in the mammalian retina. J. Physiology. 18:4393-4400.
Weber, A.J. and S. Viswanáthan (2008) The primate model of glaucoma, Chapter 24, In: Tombran-Tink J,
Barnstable C, and Shields M.B., eds. Mechanisms Of the Glaucomas: Disease Processes and
Therapeutic Modalities, Humana Press (May 2008).
Weber, A.J., C. Ramanathan, S. Viswanáthan, C.D. Harman (2010) Combined application of BDNF to the eye and brain enhances ganglion cell survival and function in the cat following optic nerve injury relative to treatment of the eye alone. Invest. Ophthalmol. Vis. Sci. 51:327-334.
Weber, A. J. (2012) Review article: Autocrine and paracrine Interactions and Neuroprotection in Glaucoma. Cell and Tissue Research Special Issue: Neuroprotection in Glaucoma. (published online: (http://link.springer.com/article/10.1007%2Fs00441-013-1556-3).
Kwon, Ki Yong, Sirowatka, Brenton, Li, Wen, Weber, Arthur (2012) Opto-μECoG array: Transparent μECoG electrode array and integrated LEDs for optogenetics, BioCAS, IEEE (Conference Journal:pp.164-167 doi: 10.1109/BioCAS.2012.6418471, URL: http://ieeexplore.ieee.org.proxy2.cl.msu.edu/stamp/stamp.jsp?tp=&arnumber=6418471&isnumb er=6418223.
Kwon, Ki Yong, Sirowatka, Brenton, Li, Wen, Weber, Arthur (2013) Opto-μECoG Array: A Hybrid Neural Interface with
Transparent μECoG Electrode Array and Integrated LEDs for Optogenetics (submitted).
Weber, A.J. and C.D. Harman (2013) Development of a BDNF-based treatment strategy for long-term
recovery of retinal morphology and function following optic nerve trauma. J. Neurotrauma 2013 (in preparation)