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MSU researcher receives $1.9 million NIH grant to study brain behavior


Shane Crandall always welcomes new challenges. It’s exploring the unknown that motivates the assistant professor in Michigan State University’s Department of Physiology to make new discoveries about the brain.

Just last month, the National Institutes of Health (NIH) awarded Crandall a five-year, $1.9 million grant to study how neocortical feedback projections influence sensory processing in the brain.

Image of Shane Crandall in his lab

Shane Crandall, MSU assistant professor of physiology and Neuroscience Program faculty member has received a $1.9 million NIH grant to study how neocortical feedback projections influence sensory processing in the brain. Credit: Tom Gennara

“A prominent but often neglected feature of the neocortex is the numerous neural connections linking higher-order cortical centers with the areas responsible for receiving and initially processing sensory signals,” said Crandall, whose primary research focuses on how different cells in our brain (also known as neurons) communicate and work together to generate behavior. “I always found it fascinating that the cortex talks mainly to itself. This curious feature implies that it may have a powerful influence on sensory processing and, thereby, its own perception.”

The neocortex is the largest and most unique part of our brains. Comprised of several functionally distinct areas, neural events generated in this brain region are essential for normal sensation, motor control, and cognition. It is the part of the brain where raw sensory information gathered by the senses integrates with past experiences to predict and drive behavior.

Given the potential power of these top-down pathways, neuroscientists have spent considerable effort trying to understand their functions, and it is generally thought that they mediate cognitive processes such as attention, prediction, expectation, and awareness. However, the complexity of these neural connections and the inability to access their processes using conventional approaches has long been a significant challenge to understanding them.

To zero in on these difficult to study pathways, Crandall’s research team will utilize new generation optogenetic technologies, which are modern research tools that integrate genetics and optical methods, allowing them to precisely control the activity of neurons with light in both isolated and intact brain preparations.

Crandall said the results of his research would provide fundamental knowledge about how the brain works and may lead to improved treatment strategies for certain neurological and psychiatric disorders that involve abnormal communication in the neocortex.

Crandall Lab
The electrophysiology equipment records and analyzes the activity of neurons in the mouse brain. Credit: Tyler Lee

“We want to be one of the first labs to determine how the neocortex influences its own sensory responsiveness at the level of cellular, synaptic, and circuit mechanisms,” Crandall said. “With several new and powerful genetic, optical, and physiological tools and support from the NIH, we are at the forefront of developing a comprehensive and mechanistic understanding of brain function.”

Despite the contributions Crandall has made to the field of neuroscience, support for the Minnesota native’s educational endeavors hasn’t always been there.

During his undergraduate studies at Boston University, an academic advisor bluntly told him he would never obtain a Ph.D.

“His words and doubt made me hungry,” Crandall recalled. “I used it to help motivate and push myself to succeed. I wanted to prove him wrong and say, ‘Look at me! I did it.’” 

Crandall went on to complete his Ph.D. in neuroscience at the University of Illinois Urbana-Champaign and his postdoctoral research at Brown University, where he received the highly prestigious K99/R00 Pathway to Independence Award from the NIH. In 2018, he became a full-time tenure-track assistant professor in the Department of Physiology in the College of Osteopathic Medicine at MSU.

“I knew I wanted to come to MSU because the Department of Physiology had an outstanding, collaborative research community and a core group of young neurophysiologists,” Crandall said. “It was a place I knew I could pursue cutting-edge neuroscience research and grow with my colleagues.”

These days, the avid Major League Baseball fan (he and his wife have visited two-thirds of all MLB stadiums) remains busy between his continued research and family of four made up of Crandall and his wife, a local educator, and their two young daughters, ages five and three. 

“I’ve always had the motivation to achieve my goals,” Crandall said.  “Coupled with a strong work ethic instilled in me by my parents, I am always looking for the next challenge. These characteristics have been key to my success, especially in my research.”  

Research reported in this publication was supported by the National Institute of Neurological Disorders and Stroke of the National Institutes of Health under Award Number R01NS117636. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

Banner image: Shane Crandall's research will provide more information about how the brain works which could lead to better treatment for certain neurological and psychiatric disorders. Credit: Tom Gennara

By: Tyler Lee