William Spielman, Ph.D.

William Spielman, Ph.D.
For over 40 years my research has been directed at understanding the regulation and dysregulation of salt and water homeostasis. More specifically, I have been interested in the control of the kidney function, its blood flow, and the kidney’s role in cardiovascular disease using a balance of molecular, cellular, organ, and whole animal approaches. This diversity of approach also serves as the basis for my efforts as a educator, by overlaying new discoveries at the molecular and cellular level on a framework of traditional and integrative physiology.

Cell physiology and signal transduction; cellular and molecular mechanisms of hormone and neurotransmitter action.
 

Professional Background
Professor of Physiology
Former Chairperson

  • BS in Biology, Westminster College, Fulton, MO
  • Ph.D. in Physiology, University of Missouri. Columbia MO
  • Captain, Medical Service Corps, US Army Reserve
  • Completed a NIH Individual NRSA Post-doctoral Fellowship, University of North Carolina, Chapel Hill, NC
  • Completed an American Heart Association sponsored Post-doctoral Fellowship, Mayo Foundation, Rochester, MN
  • Fellow of the American Heart Association and the American Physiological Society
  • Recipient of NIH Career Development Award
  • Appointed as a regular member of General Medicine B grant review study section of the National Institute of Health
  • Past Chairman of the Education Committee of the American Physiological Society
  • Research funded by the National Institutes of Health, National Science Foundation, American Heart Association, and National Kidney Foundation.
  • Appointed Visiting Professor of Pharmacology, University of Heidelberg, Heidelberg, Germany
  • Former Director of Renal Pharmacology, SmithKline Beecham Pharmaceuticals, King of Prussia, PA
  • Past President of Association of Chairpersons of Departments of Physiology
  • Board Member, Michigan Citizens for Stem Cell Research and Cures
  • Appointed Visiting Professor of Biochemistry, Geogetown University Medical School, Washington DC.
  • Appointed Visiting Scientist, Urologic Oncology Branch, National Cancer Institute, National Institutes of Health
  • Appointed Visiting Professor of Physiology, Tulane University School of Medicine, New Orleans, LA

Selected Publications
“RAMPs”, edited by W. S. Spielman and N. Parameswaran. Landis Bioscience, Springer Series: Advances in experimental medicine and biology 2012.

N. Paramaswaren and W. S. Spielman, 1. INTRODUCTION TO RAMPS. In, “RAMPs” edited by W. S. Spielman and N. Parameswaran. Landis Bioscience, Springer Series: Advances in experimental medicine and biology 2012; 744:1-11.

J. M. Bomberger, N. Parameswaran and W. S. Spielman, 3. REGULATION OF GPCR TRAFFICKING BY RAMPS. In, “RAMPs” edited by W. S. Spielman and N. Parameswaran. Landis Bioscience, Springer Series: Advances in experimental medicine and biology 2012; 744:25-34.

N. Parameswaran and W. S. Spielman, 9. PERSPECTIVES ON SOME RECENT STUDIES ON RAMPS. In, “RAMPs” edited by W. S. Spielman and N. Parameswaran. Landis Bioscience, Springer Series: Advances in experimental medicine and biology 2012; 744:105-110.

Parameswaren, N., W.S. Spielman. RAMPs: the past, present and future. Trends in Biochemical Sciences. 31(11):631-8, 2006 (top 100 g-protein publications as determined by ion channels.org)

Bomberger, J.M., N. Parameswaran, C.S. Hall, N. Aiyar, and W.S. Spielman. Novel Function For Receptor Activity Modifying Proteins (RAMPs) In Post-Endocytic Trafficking.  Journal of Biological Chemistry.  280(10):9297-307, 2005. (JBC PAPER OF WEEK AWARD).

Bomberger, J.M., W.S. Spielman, C.S. Hall, N. Parameswaran. RAMP Isoform-Specific Regulation of Adrenomedullin Receptor Trafficking by NHERF-1. Journal of Biological Chemistry, 280(25):23926-35, 2005.