Arthur Weber, Ph.D.
Glaucoma is a blinding disease characterized, in many cases, by pressure-induced trauma to the optic nerve posterior to the globe. Past research in my lab has focused on the structure-function relations that characterize neuronal degeneration within the central visual pathway following damage to the optic nerve. These studies combined conventional histological methods with intracellular recording and labeling, confocal microscopy, and video-enhanced image analysis. Our more recent work has focused on the development of treatment strategies aimed at mitigating or preventing optic nerve-related retinal degeneration and loss of visual function via the delivery of neuroprotectants to the diseased visual system. These studies employ an in vivo partial nerve crush model, osmotic mini-pump drug delivery, standard histological techniques, non-invasive electrophysiological analyses, Western blot, laser micro-dissection, and real time RT-PCR methods, to better understand the mechanisms of trauma-induced cellular degeneration and neuroprotection. Additional studies are aimed at the development of non-invasive approaches for enhancing endogenous neuroprotective mechanisms within the central visual pathway.
Weber, A.J., P.L. Kaufman, W.C. Hubbard (1998) Morphology of single ganglion cells in the glaucomatous primate retina. Invest. Ophthalmol. Vis. Sci. 39:2304-2320.
Nork, T.M., J.N. Ver Hoeve, G.L. Poulsen, R.W. Nickells, A.J. Weber, Vaegan, S.H. Sarks, H.L. Lemley and L.L. Millechia (2000) Swelling and loss of photoreceptors in chronic human and experimental glaucoma. Arch. Ophthalmol. 118:235-245.
Weber, A.J., H. Chen, W.C. Hubbard, and P.L. Kaufman (2000) Experimental glaucoma and cell size, density, and number in the primate lateral geniculate nucleus (LGN). Invest. Ophthalmol. Vis. Sci. 41: 1370-1379.
Chen, H. and A.J. Weber (2001) BDNF enhances retinal ganglion cell survival in cats with optic nerve damage. Invest. Ophthalmol. Vis. Sci. 42: 966-974.
Weber, A.J. and D. Zelenak (2001) Experimental glaucoma in the primate eye induced by injection of latex microspheres into the anterior chamber. J. Neurosci. Methods 111:39-48.
Chen, H. and A.J. Weber (2002) Expression of glia fibrillary acidic protein and glutamine synthetase by Müller cells following optic nerve damage and intravitreal application of brain-derived neurotrophin factor. Glia 38:115-125.
Chen, H. and A.J. Weber (2004) Brain-derived neurotrophic factor (BDNF) reduces tyrosine kinase B (trkB) receptor protein in the normal rat retina and following optic nerve damage. Brain Research: 1011: 99-106.
Weber, A.J. and C.D. Harman (2005) Structure-function relations of parasol cells in the normal and glaucomatous primate retina. Invest. Ophthalmol. Vis. Sci. 46:3197-3207.
Weber, A.J. and C.D. Harman (2008) BDNF preserves the dendritic morphology of α and β ganglion cells in the cat retina after optic nerve injury. Invest. Ophthalmol. Vis. Sci. 49:2456-2463.
Weber, A.J., C.D. Harman, and S. Viswanáthan (2008) Effects of optic nerve injury, glaucoma, and neuroprotection on the survival, structure, and function of ganglion cells in the mammalian retina. J. Physiology. 18:4393-4400.
Weber, A.J. and S. Viswanáthan (2008) The primate model of glaucoma, Chapter 24, In: Tombran-Tink J,Barnstable C, and Shields M.B., eds. Mechanisms of the Glaucomas: Disease Processes and Therapeutic Modalities, Humana Press (May 2008).
Weber, A.J., C. Ramanathan, S. Viswanáthan, C.D. Harman (2010) Combined application of BDNF to the eye and brain enhances ganglion cell survival and function in the cat following optic nerve injury relative to treatment of the eye alone. Invest. Ophthalmol. Vis. Sci. 51:327-334.
Weber, A. J. (2013) Review article: Autocrine and paracrine interactions and neuroprotection in glaucoma. Cell and Tissue Research 353:219-230 (Special Issue: Neuroprotection in Glaucoma).
Weber, A.J. and C.D. Harman (2013) BDNF treatment and extended recovery from optic nerve trauma in the cat. Invest Ophthalmol Vis Sci. 54: 6594-6604.
Kwon, Ki-Y, Hyung-Min Lee, Maysam Ghovanloo, Arthur Weber, and Wen Li (2015) Design, Fabrication, and Packaging of an Integrated, Wirelessly-Powered Optrode Array for Optogenetics Application. Front. Syst. Neurosci. vol. 9, no. 69. doi: 10.3389/fnsys.
Y. Jia, W. Khan, B. Lee, B. Fan, F. Madi, A. Weber, W. Li, and M. Ghovanloo, (2018) Wireless Opto-Electro Neural Interface for Experiments with Small Freely Behaving Animals", Journal of Neural Engineering. 15:1-13 (https://doi.org/10.1088/1741-2552/aac810)
Yaoyao Jia, S. Abdollah Mirbozorgi, Byunghun Lee, Wasif Khan, Fatma Madi, Arthur J. Weber, Wen Li, and Maysam Ghovanloo, (2019) “A mm-Sized Free-Floating Wirelessly Powered Implantable Optical Stimulation Device”, IEEE Xplore, 13: 608-618. 10.1109/TBCAS.2019.2918761
Kouhani, M. Jiajia Wu, Arman Tavakoli, Arthur J. Weber, and Wen Li (2019) Wireless, passive strain sensor in a doughnut-shaped contact lens for continuous non-invasive self-monitoring of intraocular pressure. Lab on a Chip (under revision).
JB Burn, AA Huang, A Weber, AM Komáromy, CH Pirie (2019 Aqueous angiography in normal canine eyes. Translational Vis Sci &Technol (under revision).
JB Burn, AS Huang, A Weber, AM Komáromy, CG Pirie (2019) Aqueous angiography in ADAMTS10-open angle glaucoma dogs before and after development of glaucoma. Translational Vis Sci &Technol (in preparation).