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Andrea Doseff, Ph.D.

Professor *
Biomedical Physical Sciences Building
567 Wilson Rd Rm 4173 (Office) Rm 4153 (Lab)
Office: (517) 884-5155
Lab: (517) 884-5142
doseffan@msu.edu
Doseff Lab
 

Education

PhD, Cold Spring Harbor Laboratory, Cold Spring Harbor, New York and State University of New York at Stony Brook.

B.Sc. Biology, Faculty of Science, University of Buenos Aires, Argentina.
 

Previous Appointments

Professor, 2015-2017, Department of Molecular Genetics, College of Arts and Sciences and Department of Cell and Molecular Physiology, College of Medicine. The Ohio State University, Columbus, Ohio.

Associate Professor, 2008-2015, Department of Molecular Genetics, College of Arts and Sciences and Department of Cell and Molecular Physiology and Department Internal Medicine, College of Medicine. The Ohio State University, Columbus, Ohio

Assistant Professor, 2002-2008, Department of Molecular Genetics, College of Arts and Sciences and Department of Internal Medicine, College of Medicine. The Ohio State University, Columbus, Ohio

Research Scientist, 1998-2001, The Ohio State University, Columbus, Ohio

Postdoctoral Fellow, 1996-1997, Cold Spring Harbor Laboratory, New York.
 

Research Interests

Main areas of research: Regulatory gene and protein networks of immune cell fate and apoptosis; anti-inflammatory and anti-carcinogenic mechanisms of phytochemicals; phytochemical target identification; the role of cell death regulators in immune-regulation and immune-oncology; foods for health.

Our research focuses in understanding the mechanisms that regulate apoptosis and cell fate. These mechanisms are essential for normal cellular and immune function, contributing to normal development and controlling cancer and other inflammatory diseases. We use genome-wide analyses, proteomics, molecular, biochemical, cellular and animal models to elucidate the gene and protein regulatory networks that regulate cell death. We are integrating these approaches to elucidate how cell death proteins and its regulators define cell fate, reduce cancer resistance and control immune-function. In addition, we study the role of plant compounds (phytochemicals) in the regulation of immune cell function. We have developed new approaches to identify targets of phytochemicals in humans, contributing to the discovery of new mechanisms by which dietary phytochemicals control cancer and immune-function. These findings are significant providing opportunities for immune-oncology and immune-regulatory therapies. Our research revealed the role of phytochemicals in halting cancer development and metastasis by modulating gene expression and RNA splicing. Towards the development of foods for health, we are working in functional foods that increase the efficacy of phytochemicals, facilitating the implementation of novel alternative approaches for the prevention and treatment of cancer and other inflammatory diseases.
 

Publications

Google Scholar List of Publications
 

SiGuE (Success in Graduate Education) Post-baccalaureate Program

Main Office
Department of Physiology
 Biomedical Physical Sciences (BPS) Building
567 Wilson Rd Rm 2201
Main Phone: 517-884-5000


Department Chairperson

Dr. Charles "Lee" Cox
Dr. Charles "Lee" Cox
BPS Building Rm 2201E
Phone: 517-884-5050
 coxclee@msu.edu

MSU Research Integrity Officer
Wills House
287 Delta Court, Room 106
Phone: 517-432-6698
 rio@msu.edu
Research Integrity Office