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Robert Root-Bernstein, Ph.D.

Root-Bernstein Website

Areas of Research Interest [PDF]

Research Interests

Peptide-neurotransmitter-drug interactions. AIDS; molecular complementarity; chemical basis of physiological interactions between peptides, monoamines, and drugs; theoretical and experimental approaches to autoimmunity and its suppression; historical and philosophical perspectives on science and its methods.

Selected Publications

Root-Bernstein RS, Rhinesmith T, Koch A, Dillon PF. (2016) Enzymatic recycling of ascorbate by glutathione-like peptides derived from aminergic G-protein coupled receptors. J Mol Recog. DOI: 10.1002/jmr.2530


Root-Bernstein RS, Pawelec K. (2016) Toward a geography of innovation: Where do Nobel Prize winners and members of the U. S. National Academy of Sciences get trained? J Genius Eminence; 1(1): 28-42. DOI: 10.18536/jge.2016.


Root-Bernstein RS, Root-Bernstein MM. (2016) The Ribosome as a Missing Link in Prebiotic Evolution II: Ribosomes Encode Ribosomal Proteins that Bind to Common Regions of their Own mRNAs and rRNAs. J Theor Biol. 397: 115-127. doi: 10.1016/j.jtbi.2016.02.030.


Root-Bernstein R. (2016) Autoimmunity and the microbiome: T-cell receptor mimicry of "self" and microbial antigens mediates self-tolerance in holobionts. Bioessays. Sep 5. doi: 10.1002/bies.201600083.


Root-Bernstein RS, Fairweather D. Complexities in the relationship between infection and autoimmunity. Current Allergy and Asthma Reports 2014, 14:407.


Root-Bernstein, Meredith, Root-Bernstein, Michele, and Root-Bernstein, Robert. Tools for thinking applied to nature: an inclusive pedagogical framework for environmental education. Oryx, 1-9, March 2014


Root-Bernstein RS. Rethinking molecular mimicry in rheumatic heart disease and autoimmune myocarditis: Laminin, collagen IV, CAR, and B1AR as initial targets of disease. Frontiers in Pediatric Rheumatology 2014, 2:85.


Root-Bernstein R, Podufaly A, Dillon PF.  Estradiol binds to insulin and insulin receptor decreasing insulin binding in vitro. Front Endocrinol (Lausanne). 2014, 5:118.


Root-Bernstein RS, Dillon PF. A common molecular motif characterizes extracellular allosteric enhancers of GPCR aminergic receptors and suggests their mechanism of action. Curr Med Chem. 2014, 21: 3673-3686.


Root-Bernstein MM, Root-Bernstein RS. The ribosome as a missing link in evolution. J Theor Biol. 2015, 367:130-58.


Norris V, Reusch R, Igarashi K, Root-Bernstein RS. Molecular complementarity between simple, universal molecules and ions limited phenotype space in the precursors of cells. Biol Direct. 2014, 10:28.


Root-Bernstein RS, Fairweather D. Rethinking autoimmune disease: A case study of autoimmune myocarditis. J Theor Biol. 2014 Dec 4. pii: S0022-5193(14)00674-2.


*Root-Bernstein R. Defining life: Products or processes? J. Biomol Struct Dyn 29(4), 631-632 (2012).


*Root-Bernstein R.  A modular hierarchy-based theory of the chemical origins of life based on molecular complementarity Acc. Chem. Res., 45 (12): 2169-2177, 2012. DOI: 10.1021/ar200209k;


*Root-Bernstein R. Molecular paleontology. Chemistry and Industry, 11 June 2012, issue 6.


*Root-Bernstein RS, Podufaly A. Autoreactive T-cell receptor (Vbeta/D/Jbeta) sequences in diabetes recognize insulin, the insulin receptor, and each other, and are targets of insulin antibodies. The Open Autoimmunity Jourrnal. 4: 10-22, 2012. [DOI: 10.2174/1876894601204010010]


*Root-Bernstein R, Root-Bernstein M. “The Necessity of Arts and Crafts for Science Education,” Educational Leadership 70 (5): 16-21, 2013.;


*Root-Bernstein R, Root-Bernstein M. “The importance of early and persistent arts and crafts education for future scientists and engineers.” NSF SEAD whitepaper, 2012:


*Root-Bernstein RS, Podufaly A., Aimone F. Antigenic Complementarity between Influenza A Virus and Haemophilus Influenzae may Drive Lethal Co-Infection Such As That Seen In 1918-19. Journal of Virology and Antivirology Resesarch (in press).


Lamore R, Root-Bernstein RS, Lawton J, Schweitzer J, Root-Bernstein MM, Roraback E, Peruski A, Van Dyke M, Fernandez L.  Arts and Crafts: Critical to Economic Innovation.  Economic Development Quarterly (in press).


*Root-Bernstein RS, Podufaly A, Dillon PF. Estradiol Binds to Insulin and the Insulin Receptor Explaining Insulin Resistance in Gestational Diabetes Mellitus, Polycystic Ovary Syndrome, Estrogen Therapies and Metabolic Syndrome. PLOS1 (under revision)