Hongbing Wang, Ph.D.
My lab investigates the cellular and molecular mechanisms underlying synaptic modification and certain aspects of adaptive behavior. We aim to understand the function of calcium-stimulated signal transduction pathways and G protein-coupled receptors. We use molecular and cellular, transgenic, electrophysiological, and behavioral approaches to identify the molecular components involved in memory formation, anxiety, depression, behavioral flexibility, and emotional stability. Some results from these efforts have led to the development of new animal models of Schizophrenia and Bipolar disorder. Our mechanistic studies have also suggested several potential therapeutic approaches to treat Fragile X Syndrome and possibly autism.
For more information, please visit our lab website (www.msu.edu/~wangho) and contact me.
Ferzin Sethna, Wei Feng, Qi Ding, Alfred J. Robison, Yue Feng, Hongbing Wang (2017) Enhanced expression of ADCY1 underlies aberrant neuronal signaling and behavior in a syndromic autism model. Nature Communications. Feb 20;8:14359. doi: 10.1038/ncomms14359.
Ferzin Sethna and Hongbing Wang (2016) Acute inhibition of mGluR5 disrupts behavioral flexibility. Neurobiol Learn Mem. 130:1-6.
Ferzin Sethna, Ming Zhang, Hanoch Kaphzan, Eric Klann, Dawn Autio, Charles L Cox, Hongbing Wang (2016) Calmodulin activity regulates group I metabotropic glutamate receptor-mediated signal transduction and synaptic depression. J Neurosci Res. 94:401-408.
Fei Zheng, Ming Zhang, Qi Ding, Ferzin Sethna, Lily Yan, Changjong Moon, Miyoung Yang, and Hongbing Wang (2016) Voluntary running depreciates the requirement of Ca2+-stimulated cAMP signaling in synaptic potentiation and memory formation. Learn Mem. 23(8):442-9.
Xianju Zhou, Zhuoyou Chen, Wenwei Yun, J Ren, Chenwei Li, and Hongbing Wang (2015) Extrasynaptic NMDA Receptor in Excitotoxicity: Function Revisited. The Neuroscientist. (4):337-44.
Ferzin Sethna, Changjong Moon, and Hongbing Wang. (2014) From FMRP Function to Potential Therapies for Fragile X Syndrome. Neurochem. Res. 39(6):1016-31.
Xianju Zhou1, Qi Ding, Zhuoyou Chen, Huifang Yun, and Hongbing Wang (2013) Involvement of GluN2A and GluN2B in synaptic and extrasynaptic NMDA receptor function and neuronal excitotoxicity. J Biol Chem. 288(33):24151-9.
Xianju Zhou, Daniel Hollern, Jiayu Liao, Eran Andrechek, and Hongbing Wang (2013) NMDA receptor-mediated excitotoxicity depends on the co-activation of synaptic and extrasynaptic receptors. Cell Death & Disease. 4:e560. doi: 10.1038/cddis.2013.82.
Ming Zhang and Hongbing Wang (2013) Mice overexpressing type 1 adenylyl cyclase show enhanced spatial memory flexibility in the absence of intact synaptic long-term depression. Learn Mem. 20: 352-357.
Ming Zhang, Daniel Storm, and Hongbing Wang. (2011) Bidirectional synaptic plasticity and spatial memory flexibility require Ca2+-stimulated adenylyl cyclases. J. Neurosci. 31(28): 10174-183.
Ming Zhang, Changjong Moon, Guy Chan, Lan Yang, Fei Zheng, Alana Conti, Lisa Muglia, Louis Muglia, Daniel Storm, and Hongbing Wang. (2008) Ca-stimulated type 8 adenylyl cyclase is required for rapid acquisition of novel spatial information and for working/episodic-like memory. J. Neurosci. 28 (18): 4736-4744.